Epithelial-Mesenchymal Transition and Immune Evasion during Lung Cancer Progression: The Chicken or the Egg?

Clin Cancer Res. 2016 Jul 15;22(14):3422-4. doi: 10.1158/1078-0432.CCR-16-0336. Epub 2016 Apr 13.

Abstract

Epithelial-mesenchymal transition (EMT) is a complex process involved in metastasis. Immune evasion is required for tumor progression and is characterized by an ineffective antitumor immune response and upregulation of immune-suppressive signals. The coexistence of EMT and adaptive immune evasion opens the possibility of a mechanistic link between these processes. Clin Cancer Res; 22(14); 3422-4. ©2016 AACRSee related article by Lou et al., p. 3630.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Disease Progression
  • Epithelial-Mesenchymal Transition / immunology*
  • Epithelial-Mesenchymal Transition / physiology*
  • Gene Expression Regulation, Neoplastic / immunology
  • Humans
  • Immune Evasion / immunology*
  • Lung / immunology
  • Lung / pathology
  • Lung Neoplasms / immunology*
  • Lung Neoplasms / pathology*
  • Up-Regulation / immunology