Resolution of spontaneous hemoabdomen secondary to peliosis hepatis following surgery and azithromycin treatment in a Bartonella species infected dog

J Vet Emerg Crit Care (San Antonio). 2016 Nov;26(6):851-857. doi: 10.1111/vec.12479. Epub 2016 Apr 13.

Abstract

Objective: To describe a case of hemoperitonium in a dog with Bartonellosis and peliosis hepatis (PH) lesions that resolved following antimicrobial therapy.

Case summary: A 3-year-11-month-old 22.5 kg female spayed mixed breed dog presented for progressive lethargy and vomiting. An abdominal ultrasonographic examination revealed moderate ascites, which when sampled was nonclotting hemorrhagic fluid. An exploratory laparotomy revealed a large volume of nonclotted blood in the dog's abdomen and blood-filled vesicular lesions dispersed diffusely along multiple lobes of the liver. Biopsies revealed lesions indicative of PH. Serology testing for Bartonella species was positive. Treatment with azithromycin resulted in Bartonella serology negative status and no further evidence of hemoperitonium at recheck examination 12 months after initial presentation.

New or unique information provided: This is the first reported case of PH and hemoperitoneum in a Bartonella species serology positive dog wherein treatment with azithromycin resulted in serology negative status. There have been no subsequent episodes of hemoperitoneum in the 12 months since treatment.

Keywords: Bartonellosis; bacillary angiomatosis; hemoabdomen; peliotic.

Publication types

  • Case Reports

MeSH terms

  • Animals
  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / therapeutic use*
  • Azithromycin / administration & dosage
  • Azithromycin / therapeutic use*
  • Bartonella Infections / diagnosis
  • Bartonella Infections / veterinary*
  • Diagnosis, Differential
  • Dog Diseases / diagnosis*
  • Dog Diseases / drug therapy
  • Dog Diseases / surgery
  • Dogs
  • Female
  • Hemoperitoneum / diagnosis
  • Hemoperitoneum / veterinary*
  • Peliosis Hepatis / diagnosis
  • Peliosis Hepatis / veterinary*

Substances

  • Anti-Bacterial Agents
  • Azithromycin