GWAS meta-analysis of 16 852 women identifies new susceptibility locus for endometrial cancer

Hum Mol Genet. 2016 Jun 15;25(12):2612-2620. doi: 10.1093/hmg/ddw092. Epub 2016 Mar 23.

Abstract

Endometrial cancer is the most common gynecological malignancy in the developed world. Although there is evidence of genetic predisposition to the disease, most of the genetic risk remains unexplained. We present the meta-analysis results of four genome-wide association studies (4907 cases and 11 945 controls total) in women of European ancestry. We describe one new locus reaching genome-wide significance (P < 5 × 10 -8) at 6p22.3 (rs1740828; P = 2.29 × 10 -8, OR = 1.20), providing evidence of an additional region of interest for genetic susceptibility to endometrial cancer.

Publication types

  • Meta-Analysis

MeSH terms

  • Chromosomes, Human, Pair 6 / genetics
  • Endometrial Neoplasms / genetics*
  • Endometrial Neoplasms / pathology
  • Female
  • Genetic Predisposition to Disease*
  • Genome-Wide Association Study*
  • Genotype
  • Humans
  • Polymorphism, Single Nucleotide
  • White People / genetics