Abstract
This article highlights the important collaboration between the U.S. NCI in Bethesda, Maryland and the Istituto Tumori in Milan, Italy that had a major impact on the development of curative regimens for breast cancer, Hodgkin's disease and diffuse large B cell lymphoma.In addition to his contribution to developing new therapies, Gianni Bonadonna played an important role in bringing highly focused, disciplined, ethical clinical trials to the European continent.
Publication types
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Biography
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Historical Article
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Review
MeSH terms
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Amsacrine / administration & dosage
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Antineoplastic Combined Chemotherapy Protocols / administration & dosage
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Antineoplastic Combined Chemotherapy Protocols / history
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Bleomycin / administration & dosage
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Breast Neoplasms / drug therapy*
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Breast Neoplasms / history
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Breast Neoplasms / mortality
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Clinical Trials as Topic / history
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Cooperative Behavior
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Cyclophosphamide / administration & dosage
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Cyclophosphamide / history
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Doxorubicin / administration & dosage
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Drug Administration Schedule
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Female
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Fluorouracil / administration & dosage
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Fluorouracil / history
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History, 20th Century
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History, 21st Century
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Hodgkin Disease / drug therapy*
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Hodgkin Disease / history
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Hodgkin Disease / mortality
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Humans
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Italy
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Life Tables
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Lymphoma, Non-Hodgkin / drug therapy*
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Lymphoma, Non-Hodgkin / history
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Lymphoma, Non-Hodgkin / mortality
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Male
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Mechlorethamine / administration & dosage
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Mechlorethamine / history
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Medical Oncology / history*
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Methotrexate / administration & dosage
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Methotrexate / history
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National Cancer Institute (U.S.)
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Prednisone / administration & dosage
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Prednisone / history
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Procarbazine / administration & dosage
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Procarbazine / history
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United States
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Vincristine / administration & dosage
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Vincristine / history
Substances
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Amsacrine
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Bleomycin
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Procarbazine
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Mechlorethamine
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Vincristine
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Doxorubicin
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Cyclophosphamide
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Fluorouracil
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Prednisone
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Methotrexate
Supplementary concepts
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ABP protocol 1
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CMF regimen
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COP protocol 2
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MABOP protocol
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MOPP protocol