Combination chemotherapy of solid tumors: an American-Italian collaboration: a celebration of the work of Gianni Bonadonna

Tumori. 2016 Mar-Apr;102(2):124-6. doi: 10.5301/tj.5000492. Epub 2016 Mar 22.

Abstract

This article highlights the important collaboration between the U.S. NCI in Bethesda, Maryland and the Istituto Tumori in Milan, Italy that had a major impact on the development of curative regimens for breast cancer, Hodgkin's disease and diffuse large B cell lymphoma.In addition to his contribution to developing new therapies, Gianni Bonadonna played an important role in bringing highly focused, disciplined, ethical clinical trials to the European continent.

Publication types

  • Biography
  • Historical Article
  • Review

MeSH terms

  • Amsacrine / administration & dosage
  • Antineoplastic Combined Chemotherapy Protocols / administration & dosage
  • Antineoplastic Combined Chemotherapy Protocols / history
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Bleomycin / administration & dosage
  • Breast Neoplasms / drug therapy*
  • Breast Neoplasms / history
  • Breast Neoplasms / mortality
  • Clinical Trials as Topic / history
  • Cooperative Behavior
  • Cyclophosphamide / administration & dosage
  • Cyclophosphamide / history
  • Doxorubicin / administration & dosage
  • Drug Administration Schedule
  • Female
  • Fluorouracil / administration & dosage
  • Fluorouracil / history
  • History, 20th Century
  • History, 21st Century
  • Hodgkin Disease / drug therapy*
  • Hodgkin Disease / history
  • Hodgkin Disease / mortality
  • Humans
  • Italy
  • Life Tables
  • Lymphoma, Non-Hodgkin / drug therapy*
  • Lymphoma, Non-Hodgkin / history
  • Lymphoma, Non-Hodgkin / mortality
  • Male
  • Mechlorethamine / administration & dosage
  • Mechlorethamine / history
  • Medical Oncology / history*
  • Methotrexate / administration & dosage
  • Methotrexate / history
  • National Cancer Institute (U.S.)
  • Prednisone / administration & dosage
  • Prednisone / history
  • Procarbazine / administration & dosage
  • Procarbazine / history
  • United States
  • Vincristine / administration & dosage
  • Vincristine / history

Substances

  • Amsacrine
  • Bleomycin
  • Procarbazine
  • Mechlorethamine
  • Vincristine
  • Doxorubicin
  • Cyclophosphamide
  • Fluorouracil
  • Prednisone
  • Methotrexate

Supplementary concepts

  • ABP protocol 1
  • CMF regimen
  • COP protocol 2
  • MABOP protocol
  • MOPP protocol

Personal name as subject

  • Gianni Bonadonna