Cytokeratin 7-negative mammary Paget's disease: A diagnostic pitfall

Pathol Res Pract. 2016 Apr;212(4):279-81. doi: 10.1016/j.prp.2016.01.004. Epub 2016 Jan 22.

Abstract

Pathologists should be aware of the existence of a rare CK7-negative variant of breast carcinoma in general, and of Paget's disease in particular. Cytokeratin 7-negative Paget's disease and CK7-negative ductal intraepithelial neoplasia (ductal carcinoma in situ) present a major diagnostic challenge for pathologists since there is limited awareness of their existence. When there is classic Paget's morphology on H&E sections, GATA3 positivity should resolve any doubts about the diagnosis in the setting of a CK7-negative neoplastic cell population.

Keywords: Breast; CK7; Cancer; GATA3; Paget's disease.

Publication types

  • Case Reports

MeSH terms

  • Biomarkers, Tumor / analysis*
  • Breast Neoplasms / diagnosis*
  • Breast Neoplasms / metabolism
  • Female
  • Humans
  • Immunohistochemistry
  • Keratin-7 / biosynthesis*
  • Middle Aged
  • Nipples / metabolism
  • Nipples / pathology
  • Paget's Disease, Mammary / diagnosis*
  • Paget's Disease, Mammary / metabolism

Substances

  • Biomarkers, Tumor
  • Keratin-7