Mex3B: a coreceptor to present dsRNA to TLR3

Cell Res. 2016 Apr;26(4):391-2. doi: 10.1038/cr.2016.29. Epub 2016 Mar 4.

Abstract

Toll-Like Receptors (TLRs) play critical roles in the early innate immune response to invading pathogens by sensing microorganisms; a number of accessory molecules have been shown to assist microbial recognition by TLRs. In a recent paper in Cell Research, Yang et al. demonstrate that Mex3B is associated with TLR3 in the endosomes and promotes dsRNA binding and proteolytic processing of TLR3, suggesting that Mex3B acts as a coreceptor of TLR3 in response to dsRNA.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Endosomes / metabolism
  • RNA, Double-Stranded / metabolism
  • Signal Transduction*
  • Toll-Like Receptor 3*
  • Toll-Like Receptors / metabolism

Substances

  • RNA, Double-Stranded
  • Toll-Like Receptor 3
  • Toll-Like Receptors