Gastrointestinal Disorders in Cystic Fibrosis

David N Assis; Steven D Freedman

doi:10.1016/j.ccm.2015.11.004

Gastrointestinal Disorders in Cystic Fibrosis

Clin Chest Med. 2016 Mar;37(1):109-18. doi: 10.1016/j.ccm.2015.11.004. Epub 2015 Dec 24.

Authors

David N Assis¹, Steven D Freedman²

Affiliations

¹ Section of Digestive Diseases, Yale School of Medicine, 333 Cedar Street, 1080 LMP, New Haven, CT 06510, USA. Electronic address: david.assis@yale.edu.
² Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA.

PMID: 26857772
DOI: 10.1016/j.ccm.2015.11.004

Abstract

Gastrointestinal (GI) manifestations commonly complicate the care of patients with cystic fibrosis (CF). Despite recent approval of CF transmembrane conductance regulator modulating agents that can improve pulmonary function, GI disorders continue to be relevant and require innovative therapies. This article discusses the most common GI complications of CF, including reflux, pancreatic insufficiency, small bowel intestinal overgrowth, distal intestinal obstruction syndrome, and GI malignancy, with emphasis on clinical presentation and management.

Keywords: Constipation; Cystic fibrosis; Distal intestinal obstruction syndrome; Dysmotility; Gastrointestinal malignancy; Pancreas insufficiency; Pancreatitis; Reflux.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Cystic Fibrosis* / complications
Cystic Fibrosis* / epidemiology
Cystic Fibrosis* / therapy
Disease Management*
Gastrointestinal Diseases* / complications
Gastrointestinal Diseases* / epidemiology
Gastrointestinal Diseases* / therapy
Global Health
Humans
Morbidity / trends