Autophagy Snuffs a Macrophage's Inner Fire

Cell Host Microbe. 2016 Jan 13;19(1):9-11. doi: 10.1016/j.chom.2015.12.015.

Abstract

Autophagy is a well-known cell-intrinsic antiviral defense mechanism. Two new studies published in this issue of Cell Host & Microbe (Lu et al., 2016; Park et al., 2016) demonstrate that deletion of autophagy in myeloid cells leads paradoxically to better control of viral infection in vivo through enhanced inflammation, leading to antiviral resistance.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Autophagy*
  • Inflammation
  • Macrophages*
  • Myeloid Cells