When endothelial cells go rogue

EMBO Mol Med. 2016 Jan 1;8(1):1-2. doi: 10.15252/emmm.201505943.

Abstract

Endothelial‐to‐mesenchymal transition (EndMT) is a poorly understood phenomenon that leads to endothelial cells acquiring a variety of different mesenchymal fates. This results in a number of pathological consequences of considerable clinical significance in diseases ranging from cavernous malformations in the brain to tissue fibrosis, atherosclerosis, and cancer. Importantly, while there appears to be a number of different triggers activating EndMT, the final common pathway driving the transition appears to be the same.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Endothelial Cells*
  • Humans