Genome Sequence of Complex HIV-1 Unique Recombinant Forms Sharing a Common Recombination Breakpoint Identified in Malaysia

Hui Ting Cheong; Kim Tien Ng; Lai Yee Ong; Yutaka Takebe; Kok Gan Chan; Clayton Koh; Haider Abdulrazzaq Abed Al-Darraji; Adeeba Kamarulzaman; Kok Keng Tee

doi:10.1128/genomeA.01220-15

Genome Sequence of Complex HIV-1 Unique Recombinant Forms Sharing a Common Recombination Breakpoint Identified in Malaysia

Genome Announc. 2015 Nov 5;3(6):e01220-15. doi: 10.1128/genomeA.01220-15.

Authors

Hui Ting Cheong¹, Kim Tien Ng¹, Lai Yee Ong¹, Yutaka Takebe², Kok Gan Chan³, Clayton Koh¹, Haider Abdulrazzaq Abed Al-Darraji¹, Adeeba Kamarulzaman¹, Kok Keng Tee⁴

Affiliations

¹ Centre of Excellence for Research in AIDS (CERiA), Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
² Centre of Excellence for Research in AIDS (CERiA), Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia AIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan School of Medicine, Yokohama City University, Yokohama, Kanagawa, Japan.
³ Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia.
⁴ Centre of Excellence for Research in AIDS (CERiA), Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia k2tee@um.edu.my.

Abstract

Three strains of HIV-1 unique recombinant forms (URFs) descended from subtypes B, B', and CRF01_AE were identified among people who inject drugs in Kuala Lumpur, Malaysia. These three URFs shared a common recombination breakpoint in the reverse transcriptase region, indicating frequent linkage within the drug-injecting networks in Malaysia.