Genes and environment in neonatal intraventricular hemorrhage

Semin Perinatol. 2015 Dec;39(8):592-603. doi: 10.1053/j.semperi.2015.09.006. Epub 2015 Oct 26.

Abstract

Emerging data suggest intraventricular hemorrhage (IVH) of the preterm neonate is a complex disorder with contributions from both the environment and the genome. Environmental analyses suggest factors mediating both cerebral blood flow and angiogenesis contribute to IVH, while candidate gene studies report variants in angiogenesis, inflammation, and vascular pathways. Gene-by-environment interactions demonstrate the interaction between the environment and the genome, and a non-replicated genome-wide association study suggests that both environmental and genetic factors contribute to the risk for severe IVH in very low-birth weight preterm neonates.

Keywords: GWAS; genes; intraventricular hemorrhage; neonate; preterm.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Apgar Score
  • Cerebral Ventricles / blood supply*
  • Female
  • Gene-Environment Interaction
  • Genetic Predisposition to Disease / epidemiology
  • Genetic Predisposition to Disease / genetics*
  • Genetic Variation
  • Genome-Wide Association Study
  • Gestational Age
  • Humans
  • Infant
  • Infant, Newborn
  • Infant, Premature
  • Intracranial Hemorrhages / etiology
  • Intracranial Hemorrhages / genetics*
  • Intracranial Hemorrhages / prevention & control
  • Pregnancy
  • Risk Factors
  • United States

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