A sympathetic view on fat by leptin

Luis Varela; Tamas L Horvath

doi:10.1016/j.cell.2015.09.016

A sympathetic view on fat by leptin

Cell. 2015 Sep 24;163(1):26-7. doi: 10.1016/j.cell.2015.09.016.

Authors

Luis Varela¹, Tamas L Horvath²

Affiliations

¹ Program in Integrative Cell Signalling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.
² Program in Integrative Cell Signalling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address: tamas.horvath@yale.edu.

PMID: 26406366
DOI: 10.1016/j.cell.2015.09.016

Abstract

Zeng et al. reveal that the lipolytic effect of the hormone leptin is mediated by sympathetic nerve fibers that directly "envelope" white adipocytes. Local activation of the sympathetic input to the fat opens new venues to circumvent central leptin resistance in obesity.

Publication types

Comment

MeSH terms

Adipose Tissue, White / metabolism*
Animals
Humans
Leptin / metabolism*
Lipolysis*

Substances

Leptin