Class II HLA interactions modulate genetic risk for multiple sclerosis

Affiliations

• ¹ Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
• ² John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, Florida, USA.
• ³ Department of Clinical Neurosciences, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.
• ⁴ Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.
• ⁵ Program in Translational NeuroPsychiatric Genomics, Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
• ⁶ Department of Medicine, Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts, USA.
• ⁷ Harvard Medical School, Boston, Massachusetts, USA.
• ⁸ Program in Medical and Population Genetics, Broad Institute of Harvard University and MIT, Cambridge, Massachusetts, USA.
• ⁹ Institute of Environmental Medicine (IMM), Karolinska Institutet, Stockholm, Sweden.
• ¹⁰ Medical Research Council (MRC) Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.
• ¹¹ Department of Neurology, University of California, San Francisco, Sandler Neurosciences Center, San Francisco, California, USA.
• ¹² HLA Laboratory, Department of Transfusion Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
• ¹³ Westmead Millennium Institute, University of Sydney, Sydney, New South Wales, Australia.
• ¹⁴ Department of Neurology, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany.
• ¹⁵ Department of Neurology, Oslo University Hospital, Ullevål, Oslo, Norway.
• ¹⁶ Department of Neurology and Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA.
• ¹⁷ Department of Genetics, Yale University School of Medicine, New Haven, Connecticut, USA.
• ¹⁸ Interdisciplinary Research Center of Autoimmune Diseases (IRCAD), Department of Health Sciences, University of Eastern Piedmont, Novara, Italy.
• ¹⁹ Nuffield Department of Clinical Neurosciences, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.
• ²⁰ Department of Neurosciences, Laboratory for Neuroimmunology, KU Leuven, Leuven, Belgium.
• ²¹ INSERM, Université Pierre et Marie Curie, CNRS, Assistance Publique-Hôpitaux de Paris (AP-HP), Département des Maladies du Système Nerveux and UMRS 1127-7225, Institut Cerveau Moelle Spinal Cord and Brain Institute, Pitié-Salpêtrière, Paris, France.
• ²² Focus Program Translational Neuroscience (FTN), Rhine Main Neuroscience Network (rmn2), Johannes Gutenberg University-Medical Center, Mainz, Germany.
• ²³ Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
• ²⁴ German Competence Network Multiple Sclerosis (KKNMS), Munich, Germany.
• ²⁵ Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
• ²⁶ Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Melbourne, Victoria, Australia.
• ²⁷ Department of Mathematics and Statistics, University of Melbourne, Parkville, Melbourne, Victoria, Australia.
• ²⁸ Platform for Genome Analytics, Institutes of Neurogenetics and Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany.
• ²⁹ Laboratory of Genetics of Neurological Complex Disorders, Institute of Experimental Neurology (INSPE), Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy.
• ³⁰ Department of Neurology, Institute of Experimental Neurology (INSPE), Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy.
• ³¹ Department of Neurology, Danish Multiple Sclerosis Center, Copenhagen University Hospital, Copenhagen, Denmark.
• ³² Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
• ³³ Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
• ³⁴ Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia.
• ³⁵ Institut für Humangenetik, Technische Universität München, Munich, Germany.
• ³⁶ Institut für Humangenetik, Helmholtz Zentrum München, Munich, Germany.
• ³⁷ Department of Neurology and Neurological Sciences, Center for Sleep Sciences and Medicine, Stanford University, Stanford, California, USA.
• ³⁸ Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
• ³⁹ Broad Institute of Harvard University and MIT, Cambridge, Massachusetts, USA.
• ⁴⁰ Harvard NeuroDiscovery Center, Harvard Medical School, Boston, Massachusetts, USA.
• ⁴¹ University of Oslo, Oslo, Norway.