Adaption by Rewiring Epigenetic Landscapes

Cell Stem Cell. 2015 Sep 3;17(3):249-50. doi: 10.1016/j.stem.2015.08.015.

Abstract

Embryonic stem cells (ESCs) generally rely on repressive histone modifications to silence retrotransposons, rather than DNA methylation as in differentiated cells. In this issue of Cell Stem Cell, He et al. (2015) show that Daxx/Atrx repress transposons in ESCs devoid of 5mC, demonstrating dynamic reorganization of epigenetic networks and crosstalk between distinct repressive mechanisms to maintain transposon silencing.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Adaptor Proteins, Signal Transducing / metabolism*
  • Animals
  • Carrier Proteins / metabolism*
  • DNA Helicases / metabolism*
  • DNA Methylation*
  • Histones / metabolism*
  • Humans
  • Intracellular Signaling Peptides and Proteins / metabolism*
  • Lysine / metabolism*
  • Nuclear Proteins / metabolism*
  • Tandem Repeat Sequences / genetics*

Substances

  • Adaptor Proteins, Signal Transducing
  • Carrier Proteins
  • Histones
  • Intracellular Signaling Peptides and Proteins
  • Nuclear Proteins
  • DNA Helicases
  • Lysine