Abstract
Embryonic stem cells (ESCs) generally rely on repressive histone modifications to silence retrotransposons, rather than DNA methylation as in differentiated cells. In this issue of Cell Stem Cell, He et al. (2015) show that Daxx/Atrx repress transposons in ESCs devoid of 5mC, demonstrating dynamic reorganization of epigenetic networks and crosstalk between distinct repressive mechanisms to maintain transposon silencing.
Copyright © 2015 Elsevier Inc. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Comment
MeSH terms
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Adaptor Proteins, Signal Transducing / metabolism*
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Animals
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Carrier Proteins / metabolism*
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DNA Helicases / metabolism*
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DNA Methylation*
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Histones / metabolism*
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Humans
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Intracellular Signaling Peptides and Proteins / metabolism*
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Lysine / metabolism*
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Nuclear Proteins / metabolism*
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Tandem Repeat Sequences / genetics*
Substances
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Adaptor Proteins, Signal Transducing
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Carrier Proteins
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Histones
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Intracellular Signaling Peptides and Proteins
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Nuclear Proteins
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DNA Helicases
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Lysine