Sodium-activated macrophages: the salt mine expands

Cell Res. 2015 Aug;25(8):885-6. doi: 10.1038/cr.2015.91. Epub 2015 Jul 28.

Abstract

High sodium consumption has been raising interest as a putative environmental factor linking Western lifestyle to the growing epidemic of autoimmune and inflammatory diseases. Now Zhang and colleagues show that high sodium drives macrophage to acquire a new proinflammatory effector phenotype with a distinct signature, paving the path to assess the role of salt-activated macrophages in human disease.

Publication types

  • Comment

MeSH terms

  • Animals
  • Humans
  • Macrophage Activation*
  • Macrophages / drug effects*
  • Sodium Chloride / adverse effects*

Substances

  • Sodium Chloride