PP043. Oxidative stress in the maternal body also affects the fetus in preeclamptic women with fetal growth restriction

Kazushi Watanabe; Ai Iwasaki; Toshitaka Mori; Chiharu Kimura; Hiroshi Matsushita; Koichi Shinohara; Akihiko Wakatsuki

doi:10.1016/j.preghy.2013.04.070

PP043. Oxidative stress in the maternal body also affects the fetus in preeclamptic women with fetal growth restriction

Pregnancy Hypertens. 2013 Apr;3(2):82. doi: 10.1016/j.preghy.2013.04.070. Epub 2013 Jun 6.

Authors

Kazushi Watanabe, Ai Iwasaki, Toshitaka Mori, Chiharu Kimura, Hiroshi Matsushita, Koichi Shinohara, Akihiko Wakatsuki

PMID: 26105901
DOI: 10.1016/j.preghy.2013.04.070

Abstract

The purpose of the present study was to determine whether oxidative stress occurring in the maternal body also affects the fetus in preeclamptic women with FGR. We ∥@consecutively recruited 17 preeclamptic women with FGR, 16 preeclamptic women without FGR, and 16 healthy pregnant women with uncomplicated pregnancy. We measured concentrations of derivatives of reactive oxygen metabolites (d-ROMs) as a marker of oxygen free radicals in a maternal vein, umbilical artery, and umbilical vein. ∥@Maternal d-ROM levels were higher in preeclamptic groups compared to the control group. Umbilical artery and vein d-ROM levels were elevated in preeclamptic women with FGR compared to the control group. Umbilical artery d-ROM levels were significantly higher than in the vein in preeclamptic women with FGR, but not in those without FGR. Umbilical arterial blood pH was significantly lower in preeclamptic women with FGR. The partial pressure of oxygen (PaO2) in umbilical arterial blood tended to be lower in preeclamptic women with FGR (p=0.08). The partial pressure of carbon dioxide (PaCO2) in umbilical arterial blood was significantly higher in preeclamptic women with FGR. These results indicate that oxidative stress occurring in the maternal body also affects the fetus in preeclamptic women with FGR.