Are ERAD components involved in cross-presentation?

Mol Immunol. 2015 Dec;68(2 Pt A):112-5. doi: 10.1016/j.molimm.2015.05.002. Epub 2015 May 23.

Abstract

A long unanswered question in the antigen presentation field is how exogenous antigens cross-presented by Major Histocompatibility Complex class I (MHC-I) molecules to CD8(+) T cells are translocated into the cytosol. Here we discuss the known mechanisms involved in this process with a focus on the hypothesized role of the machinery that functions in endoplasmic reticulum-associated degradation (ERAD). Other potential mechanisms of antigen entry to the cytosol are also discussed.

Keywords: Antigen processing; Cross-presentation; Dendritic cells; ERAD; MHC.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Antigen Presentation*
  • Antigens / genetics
  • Antigens / immunology*
  • CD8-Positive T-Lymphocytes / cytology
  • CD8-Positive T-Lymphocytes / immunology
  • Cross-Priming
  • Cytosol / immunology
  • Cytosol / metabolism
  • Dendritic Cells / cytology
  • Dendritic Cells / immunology*
  • Dendritic Cells / metabolism
  • Endoplasmic Reticulum / genetics
  • Endoplasmic Reticulum / immunology
  • Endoplasmic Reticulum / metabolism
  • Endoplasmic Reticulum-Associated Degradation / genetics
  • Endoplasmic Reticulum-Associated Degradation / immunology*
  • Histocompatibility Antigens Class I / genetics
  • Histocompatibility Antigens Class I / immunology*
  • Humans
  • Nuclear Proteins / genetics
  • Nuclear Proteins / immunology
  • Protein Transport
  • Ubiquitin-Protein Ligases / genetics
  • Ubiquitin-Protein Ligases / immunology

Substances

  • Antigens
  • Histocompatibility Antigens Class I
  • Nuclear Proteins
  • nuclear protein import factor p97
  • Ubiquitin-Protein Ligases