Serious head trauma preceding essential tremor: A population-based study (NEDICES)

Background: An association between head trauma and essential tremor (ET) has not been formally assessed. Our purpose was to assess the association between serious head trauma and ET.

Methods: History of head trauma was assessed in 274 ET cases and 3201 controls in the Neurological Disorders in Central Spain (NEDICES) study, a population-based study in central Spain. Head trauma was defined as serious only if the subject reported that the trauma resulted in loss of consciousness, hospitalization, or a visit to the emergency department.

Results: Thirty-two (11.7%) of 274 ET cases vs. 260 (8.1%) of 3201 controls reported a history of serious head trauma (p=0.04). In an adjusted logistic regression analysis, participants who reported serious head trauma were 52% more likely to have ET (odds ratio [OR] 1.52; 95% confidence interval [CI] 1.02-2.27, p=0.04). The odds of ET increased with increasing age of head trauma: adjusted ORs=1.23 (95% CI 0.43-3.46, p = 0.70) for serious head trauma that occurred before age 18 years, adjusted OR=1.49 (95% CI 0.62-3.55, p = 0.37) for serious head trauma between ages 18 to 39 years, and adjusted OR=1.61 (95% CI 1.00-2.57, p = 0.04) for serious head trauma at age 40 years or older.

Conclusions: Our study suggests that serious head trauma, especially when it occurs after 40 years, is associated with increased odds of ET. Additional studies are needed to reproduce this novel finding.