HIV suppression by host restriction factors and viral immune evasion

Xiaofei Jia; Qi Zhao; Yong Xiong

doi:10.1016/j.sbi.2015.04.004

HIV suppression by host restriction factors and viral immune evasion

Curr Opin Struct Biol. 2015 Apr:31:106-14. doi: 10.1016/j.sbi.2015.04.004. Epub 2015 May 16.

Authors

Xiaofei Jia¹, Qi Zhao¹, Yong Xiong²

Affiliations

¹ Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA.
² Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA. Electronic address: yong.xiong@yale.edu.

Abstract

Antiviral restriction factors are an integral part of the host innate immune system that protects cells from viral pathogens, such as human immunodeficiency virus (HIV). Studies of the interactions between restriction factors and HIV have greatly advanced our understanding of both the viral life cycle and basic cell biology, as well as provided new opportunities for therapeutic intervention of viral infection. Here we review the recent developments towards establishing the structural and biochemical bases of HIV inhibition by, and viral countermeasures of, the restriction factors TRIM5, MxB, APOBEC3, SAMHD1, and BST2/tetherin.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Animals
DNA, Viral / genetics
HIV / genetics
HIV / physiology*
Humans
Immune Evasion*
Mutation
Reverse Transcription

Substances

DNA, Viral

Abstract

Publication types

MeSH terms

Substances

Grants and funding