Two tales (tails) of SAMHD1 destruction by Vpx

Xiaoyun Ji; Yong Xiong

doi:10.1016/j.chom.2015.03.013

Two tales (tails) of SAMHD1 destruction by Vpx

Cell Host Microbe. 2015 Apr 8;17(4):425-7. doi: 10.1016/j.chom.2015.03.013.

Authors

Xiaoyun Ji¹, Yong Xiong²

Affiliations

¹ Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA.
² Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA. Electronic address: yong.xiong@yale.edu.

PMID: 25856752
DOI: 10.1016/j.chom.2015.03.013

Abstract

The lentivirus protein Vpx/Vpr recognizes the host restriction factor SAMHD1 at either its N- or C-terminal tail and targets it for destruction by the cellular protein degradation machinery. In this issue of Cell Host & Microbe, Schwefel et al. (2015) report the structural basis of SAMHD1 N-terminal targeting by Vpx.

Publication types

Comment

MeSH terms

Animals
Carrier Proteins / chemistry*
Host-Pathogen Interactions*
Monomeric GTP-Binding Proteins / chemistry*
Protein Multimerization*
Viral Regulatory and Accessory Proteins / chemistry*

Substances

Carrier Proteins
Viral Regulatory and Accessory Proteins
Monomeric GTP-Binding Proteins