Abstract
Sixteen human breast carcinomas were subjected to molecular biological and biochemical analyses to determine tumor cell MDR-1 (P-glycoprotein) levels and progesterone receptor content. The results of these analyses disclosed a strong reciprocal and inverse correlation between levels of tumor cell-specific MDR-1 complementary hybrids and progesterone receptor content. These results suggest that the mechanisms which control expression of the P-glycoprotein gene and the progesterone receptor are interrelated and antagonistic, a result with obvious molecular biological, physiological, and clinical implications.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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ATP Binding Cassette Transporter, Subfamily B, Member 1
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Biomarkers, Tumor / analysis
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Biopsy
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Breast Neoplasms / genetics
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Breast Neoplasms / metabolism*
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Breast Neoplasms / pathology
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DNA Probes
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Drug Resistance / genetics*
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Female
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Humans
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Membrane Glycoproteins / genetics*
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Neoplasm Proteins / genetics*
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Nucleic Acid Hybridization
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Receptors, Progesterone / analysis
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Receptors, Progesterone / metabolism*
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Transcription, Genetic*
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Tumor Cells, Cultured / metabolism
Substances
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ATP Binding Cassette Transporter, Subfamily B, Member 1
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Biomarkers, Tumor
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DNA Probes
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Membrane Glycoproteins
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Neoplasm Proteins
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Receptors, Progesterone