Ritonavir-boosted indinavir but not lopinavir inhibits erythrocytic stage Plasmodium knowlesi malaria in rhesus macaques

Bioorg Med Chem Lett. 2015 Apr 1;25(7):1538-40. doi: 10.1016/j.bmcl.2015.02.014. Epub 2015 Feb 16.

Abstract

The inhibitive activities of the human immunodeficiency virus protease inhibitors ritonavir (RTV) boosted indinavir (IDV) and RTV boosted lopinavir (LPV) for erythrocytic stage malaria were evaluated in rhesus macaques. The IDV/RTV regimen effectively inhibits the replication of Plasmodium knowlesi with clinically relevant doses, whereas the LPV/RTV regimen did not show activity against plasmodium infection.

Keywords: Indinavir; Lopinavir; Plasmodium knowlesi; Rhesus macaques; Ritonavir.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antimalarials / pharmacology*
  • Dose-Response Relationship, Drug
  • Erythrocytes / drug effects*
  • Erythrocytes / parasitology
  • Indinavir / pharmacology*
  • Macaca mulatta
  • Malaria / drug therapy*
  • Malaria / parasitology
  • Molecular Structure
  • Parasitic Sensitivity Tests
  • Plasmodium knowlesi / drug effects*
  • Ritonavir / pharmacology*
  • Structure-Activity Relationship

Substances

  • Antimalarials
  • Indinavir
  • Ritonavir