Gamma-delta T-cell lymphomas (GD-TCL) are rare and rapidly fatal neoplasms that are often associated with Hemophagocytic Lymphohistiocytosis (HLH), a syndrome of fevers, cytopenias, and multiorgan failure that often leads to a rapid death. We report the first case demonstrating an association between GD-TCL, HLH, and cardiac amyloidosis, presenting a novel mechanism for rapid deterioration in these patients.
Keywords: Amyloidosis; cutaneous T-cell lymphoma; gamma–delta; hemophagocytic lymphohistiocytosis; primary cutaneous gamma–delta T-cell lymphoma.