PTENtiating autoimmunity through Treg cell deregulation

John P Ray; Joe Craft

doi:10.1038/ni.3082

PTENtiating autoimmunity through Treg cell deregulation

Nat Immunol. 2015 Feb;16(2):139-40. doi: 10.1038/ni.3082.

Authors

John P Ray¹, Joe Craft²

Affiliations

¹ Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA.
² Department of Immunobiology and Department of Internal Medicine (Rheumatology), Yale University School of Medicine, New Haven, Connecticut, USA.

PMID: 25594458
PMCID: PMC4447107
DOI: 10.1038/ni.3082

Abstract

Regulatory T (T_reg) cells require PTEN to block PI3K signaling while maintaining Foxp3 expression. In the absence of PTEN, T_reg cells lose Foxp3 expression and their suppressive function, leading to a systemic increase in interferon-γ secretion, with consequent expansion of pathogenic T helper 1 and follicular B helper T cells and systemic autoimmunity.

MeSH terms

Autoimmunity / genetics*
Forkhead Transcription Factors / metabolism
Homeostasis
Humans
Interleukin-2 / metabolism
Interleukin-2 Receptor alpha Subunit / metabolism
PTEN Phosphohydrolase / metabolism*
Signal Transduction
T-Lymphocytes, Regulatory / enzymology*
T-Lymphocytes, Regulatory / immunology
T-Lymphocytes, Regulatory / pathology*

Substances

FOXP3 protein, human
Forkhead Transcription Factors
Interleukin-2
Interleukin-2 Receptor alpha Subunit
PTEN Phosphohydrolase

Abstract

MeSH terms

Substances

Grants and funding