Jahanyne, an apoptosis-inducing lipopeptide from the marine cyanobacterium Lyngbya sp

Arihiro Iwasaki; Osamu Ohno; Shinpei Sumimoto; Hidetoshi Ogawa; Kim Anh Nguyen; Kiyotake Suenaga

doi:10.1021/ol5036722

Jahanyne, an apoptosis-inducing lipopeptide from the marine cyanobacterium Lyngbya sp

Org Lett. 2015 Feb 6;17(3):652-5. doi: 10.1021/ol5036722. Epub 2015 Jan 12.

Authors

Arihiro Iwasaki¹, Osamu Ohno, Shinpei Sumimoto, Hidetoshi Ogawa, Kim Anh Nguyen, Kiyotake Suenaga

Affiliation

¹ Department of Chemistry, Keio University , 3-14-1, Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223-8522, Japan.

PMID: 25582897
DOI: 10.1021/ol5036722

Abstract

An acetylene-containing lipopeptide, jahanyne, was isolated from the marine cyanobacterium Lyngbya sp. Its gross structure was established by spectroscopic analyses, and the absolute configuration was clarified based on a combination of chiral HPLC analyses, spectroscopic analyses, and derivatization reactions. Jahanyne significantly inhibited the growth of human cancer cells and induced apoptosis in HeLa cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Apoptosis / drug effects
Chromatography, High Pressure Liquid
Cyanobacteria / chemistry*
Drug Screening Assays, Antitumor
HeLa Cells
Humans
Lipopeptides / chemistry
Lipopeptides / isolation & purification*
Lipopeptides / pharmacology*
Lyngbya Toxins / chemistry*
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Tumor Cells, Cultured

Substances

Lipopeptides
Lyngbya Toxins
jahanyne