Super-enhancer transcription converges on AID

Jukka Alinikula; David G Schatz

doi:10.1016/j.cell.2014.12.007

Super-enhancer transcription converges on AID

Cell. 2014 Dec 18;159(7):1490-2. doi: 10.1016/j.cell.2014.12.007.

Authors

Jukka Alinikula¹, David G Schatz²

Affiliations

¹ Department of Immunobiology, Yale University School of Medicine and Howard Hughes Medical Institute, 300 Cedar Street, Box 208011, New Haven, CT 06520-8011, USA.
² Department of Immunobiology, Yale University School of Medicine and Howard Hughes Medical Institute, 300 Cedar Street, Box 208011, New Haven, CT 06520-8011, USA. Electronic address: david.schatz@yale.edu.

PMID: 25525869
DOI: 10.1016/j.cell.2014.12.007

Abstract

AID mis-targeting is poorly understood but contributes significantly to B cell genome instability. Two new papers in Cell reveal that AID mistargeting occurs primarily in gene bodies within a nuclear microenvironment characterized by high levels of transcriptional activity, interconnected transcriptional regulatory elements, and overlapping sense and antisense (convergent) transcription.

Publication types

Research Support, Non-U.S. Gov't

Grants and funding

Howard Hughes Medical Institute/United States