Producing GM-CSF: a unique T helper subset?

Dietmar Herndler-Brandstetter; Richard A Flavell

doi:10.1038/cr.2014.155

Producing GM-CSF: a unique T helper subset?

Cell Res. 2014 Dec;24(12):1379-80. doi: 10.1038/cr.2014.155. Epub 2014 Nov 21.

Authors

Dietmar Herndler-Brandstetter¹, Richard A Flavell²

Affiliations

¹ Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
² 1] Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA [2] Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA.

Abstract

GM-CSF-producing helper T cells have previously been identified to serve a nonredundant function in the initiation of autoimmune inflammation. An article by Sheng et al. recently published by Cell Research now suggests that the differentiation program of GM-CSF-producing cells from naïve CD4 T cells is distinct from that of Th1 and Th17 cells, and is regulated by the IL-7-STAT5 axis.

Publication types

Comment

MeSH terms

Animals
Encephalomyelitis, Autoimmune, Experimental / immunology*
Granulocyte-Macrophage Colony-Stimulating Factor / immunology*
STAT5 Transcription Factor / immunology*
T-Lymphocytes, Helper-Inducer / immunology*

Substances

STAT5 Transcription Factor
Granulocyte-Macrophage Colony-Stimulating Factor