How the immune system spots tumors

Elife. 2014 Sep 24:3:e04476. doi: 10.7554/eLife.04476.

Authors

Yasutaka Okabe¹, Ruslan Medzhitov²

Affiliations

¹ Yasutaka Okabe is in the Department of Immunobiology, Yale University School of Medicine, New Haven, United States.
² Ruslan Medzhitov is an eLife reviewing editor, and is in the Department of Immunobiology, Yale University School of Medicine, New Haven, United States ruslan.medzhitov@yale.edu.

Abstract

The receptor protein Dectin-1 recognizes structures found on cancerous cells, and then triggers an anti-tumor immune response.

Keywords: Dectin-1; IRF; NK cell; cancer; immunology; innate immunity; mouse.

Publication types

Comment

MeSH terms

Animals
Humans
Immunity, Innate / immunology*
Lectins, C-Type / metabolism*
Melanoma, Experimental / immunology*
Melanoma, Experimental / pathology*

Substances

Lectins, C-Type
dectin 1

Grants and funding

UL1 TR000142/TR/NCATS NIH HHS/United States