Abstract
In this report, we designed a highly bright bifunctional curcumin analogue CRANAD-28. In vivo two-photon imaging suggested that CRANAD-28 could penetrate the blood brain barrier (BBB) and label plaques and cerebral amyloid angiopathies (CAAs). We also demonstrated that this imaging probe could inhibit the crosslinking of amyloid beta induced either by copper or by natural conditions.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Alzheimer Disease / metabolism
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Alzheimer Disease / pathology
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Amyloid beta-Peptides / chemistry*
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Amyloid beta-Peptides / metabolism
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Animals
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Blood-Brain Barrier / drug effects
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Blood-Brain Barrier / metabolism
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Brain / pathology
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Copper / chemistry
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Curcumin / chemistry*
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Curcumin / pharmacology
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Humans
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Ions / chemistry
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Mice
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Mice, Transgenic
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Photons
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Protein Binding
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Spectroscopy, Near-Infrared
Substances
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Amyloid beta-Peptides
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Ions
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Copper
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Curcumin