The principle of membrane fusion in the cell (Nobel lecture)

James Edward Rothman

doi:10.1002/anie.201402380

The principle of membrane fusion in the cell (Nobel lecture)

Angew Chem Int Ed Engl. 2014 Nov 17;53(47):12676-94. doi: 10.1002/anie.201402380. Epub 2014 Aug 1.

Author

James Edward Rothman¹

Affiliation

¹ Department of Cell Biology, Yale University, 333 Cedar Street, CT 06520 New Haven (USA).

PMID: 25087728
DOI: 10.1002/anie.201402380

Abstract

Cells contain small membrane-enclosed vesicles which transport many kinds of cargo between the compartments of the cell. The result is a choreographed program of secretory, biosynthetic, and endocytic protein traffic that serves the cell's internal physiologic needs.

Keywords: Nobel lecture; SNARE; cellular biology; membrane fusion; vesicle transport.

Publication types

Lecture

MeSH terms

Animals
Cells / cytology*
Cells / metabolism*
Humans
Membrane Fusion*
Nobel Prize