microManaging mitochondrial translation

Jessica Nouws; Gerald S Shadel

doi:10.1016/j.cell.2014.07.010

microManaging mitochondrial translation

Cell. 2014 Jul 31;158(3):477-8. doi: 10.1016/j.cell.2014.07.010.

Authors

Jessica Nouws¹, Gerald S Shadel²

Affiliations

¹ Department of Pathology, Yale School of Medicine, New Haven, CT 06437, USA.
² Department of Pathology, Yale School of Medicine, New Haven, CT 06437, USA; Department of Genetics, Yale School of Medicine, New Haven, CT 06437, USA. Electronic address: gerald.shadel@yale.edu.

PMID: 25083863
DOI: 10.1016/j.cell.2014.07.010

Abstract

Regulation of gene expression in mammalian mitochondria by microRNAs is reported by Zhang et al. During muscle cell differentiation, localization of a miRNA is increased within mitochondria, where it interacts with Ago2 to selectively activate translation of mtDNA-encoded mRNAs. The findings represent a new mitochondrial regulatory pathway and a potentially powerful means to purposefully manipulate mtDNA expression.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Cell Differentiation*
MicroRNAs / metabolism*
Mitochondria / metabolism*
Myoblasts / metabolism*
Myocytes, Cardiac / metabolism*
Protein Biosynthesis*

Substances

MicroRNAs
Mirn1 microRNA, mouse