Regulating the diverse outcomes of interferon's interference

Heather D Marshall; Susan M Kaech

doi:10.1016/j.it.2014.07.002

Regulating the diverse outcomes of interferon's interference

Trends Immunol. 2014 Aug;35(8):353-4. doi: 10.1016/j.it.2014.07.002. Epub 2014 Jul 19.

Authors

Heather D Marshall¹, Susan M Kaech²

Affiliations

¹ Department of Immunobiology, Yale University School of Medicine, New Haven 06520, CT, USA.
² Department of Immunobiology, Yale University School of Medicine, New Haven 06520, CT, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA. Electronic address: susan.kaech@yale.edu.

Abstract

Regulatory T cells are crucial for preventing autoimmunity, but how their function is restrained to allow optimal effector T cells responses in appropriate contexts is unclear. In a recent paper in the Journal of Experimental Medicine, Campbell and colleagues demonstrate that virus-induced type I interferon acts directly on Treg cells to allow for functional antiviral T cell responses.

Publication types

Introductory Journal Article

MeSH terms

Animals
Cytotoxicity, Immunologic
Humans
Immune Tolerance
Immunologic Memory
Interferon Type I / immunology*
Mice
Mice, Knockout
STAT Transcription Factors / metabolism
T-Lymphocyte Subsets / immunology*
T-Lymphocyte Subsets / virology
T-Lymphocytes, Regulatory / immunology*
T-Lymphocytes, Regulatory / virology
Virus Diseases / immunology*

Substances

Interferon Type I
STAT Transcription Factors

Abstract

Publication types

MeSH terms

Substances

Grants and funding