Foreign body giant cell reaction to tarSys™ xenograft

J Cutan Pathol. 2014 Oct;41(10):771-4. doi: 10.1111/cup.12374. Epub 2014 Sep 2.

Abstract

Objective: A foreign body giant cell (FBGC) reaction may occur in response to implanted xenogenic biomaterials. Here we report a FBGC reaction to the recently introduced xenogenic biomaterial, tarSys™, used for correction of lower eyelid retraction.

Method: A retrospective chart review of two patients with FBGC reaction to tarSys™ implantation was performed.

Results: Two patients (aged 51, 58 year) with lower eyelid retraction underwent surgical implantation of tarSys™ spacer grafts for correction. Both patients subsequently experienced chronic swelling requiring graft removal. Examination of the specimens showed a palisading FBGC reaction around acellular pink fibrillar material.

Conclusion: A FBGC reaction may follow implantation of the tarSys™ xenograft.

Keywords: allograft; eyelid; foreign body giant cell reaction; rejection; xenograft.

Publication types

  • Case Reports

MeSH terms

  • Biocompatible Materials / administration & dosage
  • Biocompatible Materials / adverse effects*
  • Eyelids / pathology
  • Eyelids / surgery*
  • Female
  • Foreign-Body Reaction / pathology*
  • Giant Cells, Foreign-Body / immunology
  • Giant Cells, Foreign-Body / pathology
  • Graft Rejection / diagnosis
  • Heterografts / transplantation*
  • Humans
  • Male
  • Middle Aged
  • Retrospective Studies

Substances

  • Biocompatible Materials