Exploiting endogenous anti-inflammatory pathways as a therapeutic approach to multiorgan inflammatory disease

John L Wallace

doi:10.1016/j.ajpath.2014.05.001

Exploiting endogenous anti-inflammatory pathways as a therapeutic approach to multiorgan inflammatory disease

Am J Pathol. 2014 Aug;184(8):2154-5. doi: 10.1016/j.ajpath.2014.05.001. Epub 2014 Jul 10.

Author

John L Wallace¹

Affiliation

¹ Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada. Electronic address: altapharm@hotmail.com.

PMID: 25016432
DOI: 10.1016/j.ajpath.2014.05.001

Abstract

This Commentary highlights the article by Montero-Melendez et al, revealing novel protective properties of endogenous melanocortin receptor 3 on periodontal status in health and disease and suggesting a new genus of anti-arthritic bone-sparing therapeutics.

Publication types

Comment

MeSH terms

Animals
Arthritis, Experimental / metabolism*
Arthritis, Rheumatoid / metabolism*
Male
Periodontal Diseases / metabolism*
Receptor, Melanocortin, Type 3 / metabolism*

Substances

Receptor, Melanocortin, Type 3