Multimeric grain-marked micelles for highly efficient photodynamic therapy and magnetic resonance imaging of tumors

Int J Pharm. 2014 Aug 25;471(1-2):166-72. doi: 10.1016/j.ijpharm.2014.05.028. Epub 2014 May 22.

Abstract

Multimeric grain-marked micelles consisting of an inner core micelle (for Fe3O4 encapsulation) and outer multi-grain micelles (for chlorin e6 (Ce6, a model drug) encapsulation) were fabricated using a micelle-to-micelle conjugation method. Grain micelles (mono-thiol functionalized micelles) were chemically linked to the surface of the core micelle (multi-maleimide functionalized micelle). These micelles enable discrete compartments for Ce6 and iron oxide (Fe3O4) that enable a significantly increased in vivo photodynamic tumor inhibition while preserving high contrast magnetic resonance (MR) imaging of the tumor in vivo.

Keywords: Chlorin e6 (Ce6); Grain-marked micelles; Magnetic resonance imaging; Multimeric micelles; Photodynamic therapy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Chlorophyllides
  • Drug Carriers / chemistry*
  • Drug Liberation
  • Female
  • Humans
  • Magnetic Resonance Imaging / methods*
  • Magnetite Nanoparticles / chemistry*
  • Mice, Nude
  • Micelles
  • Neoplasms* / drug therapy
  • Neoplasms* / pathology
  • Photochemotherapy / methods*
  • Porphyrins / administration & dosage*
  • Porphyrins / chemistry
  • Radiation-Sensitizing Agents / administration & dosage*
  • Radiation-Sensitizing Agents / chemistry
  • Surface Properties
  • Xenograft Model Antitumor Assays

Substances

  • Chlorophyllides
  • Drug Carriers
  • Magnetite Nanoparticles
  • Micelles
  • Porphyrins
  • Radiation-Sensitizing Agents
  • phytochlorin