Abstract
In this pilot study, we analyzed serum insulin-like growth factor 1 (IGF-1)- and IGF-binding protein-3-for-age z scores from 54 inflammatory bowel disease children with no, temporary, or permanent growth impairment. Although our findings did not reach statistical significance, patients with permanent linear growth impairment had lower IGF-1-for-age z scores (-1.76 [-2.25 to -0.43]) compared with those with no or temporary growth impairment (-0.84 [-1.49 to -0.3]) and -1.16 [-1.59 to -1.51], respectively). IGF-binding protein-3 levels were similar across the 3 groups. In the absence of significant inflammation and malnutrition, lower IGF-1-for-age z scores may help distinguish patients likely to have permanent growth impairment from those whose growth impairment is likely to be temporary.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adrenal Cortex Hormones / therapeutic use
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Age Factors
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Blood Sedimentation
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Body Mass Index
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Body Weight
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C-Reactive Protein / metabolism
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Child
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Child Development / physiology*
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Female
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Growth Disorders / blood*
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Growth Disorders / etiology
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Humans
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Inflammatory Bowel Diseases / blood*
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Inflammatory Bowel Diseases / complications
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Inflammatory Bowel Diseases / drug therapy
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Insulin-Like Growth Factor Binding Protein 3 / blood*
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Insulin-Like Growth Factor I / metabolism*
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Interleukin-6 / blood
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Male
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Nutrition Assessment
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Pilot Projects
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Predictive Value of Tests
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Retrospective Studies
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Serum Albumin / metabolism
Substances
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Adrenal Cortex Hormones
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IGF1 protein, human
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Insulin-Like Growth Factor Binding Protein 3
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Interleukin-6
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Serum Albumin
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Insulin-Like Growth Factor I
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C-Reactive Protein