Nanotechnology in medicine: nanofilm biomaterials

Yale J Biol Med. 2013 Dec 13;86(4):527-36.

Abstract

By interrogating nature at the length scale of important biological molecules (proteins, DNA), nanotechnology offers great promise to biomedicine. We review here our recent work on nanofilm biomaterials: "nanoscopically" thin, functional, polymer-based films serving as biocompatible interfaces. In one thrust, films containing carbon nanotubes are shown to be highly antimicrobial and, thus, to be promising as biomedical device materials inherently resistive to microbial infection. In another thrust, strategies are developed toward films of independently controllable bioactivity and mechanical rigidity - two key variables governing typical biological responses.

Keywords: biomaterial; carbon nanotube; layer-by-layer; nanofilm; nanotechnology; polyelectrolyte.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Anti-Infective Agents / chemistry
  • Anti-Infective Agents / pharmacology
  • Biocompatible Materials / chemistry*
  • Biocompatible Materials / pharmacology
  • Cell Adhesion
  • Cell Line
  • Escherichia coli / drug effects
  • Humans
  • Nanomedicine / methods*
  • Nanotechnology / methods*
  • Nanotubes, Carbon / chemistry*

Substances

  • Anti-Infective Agents
  • Biocompatible Materials
  • Nanotubes, Carbon