Cortical projection neurons: sprung from the same root

Neuron. 2013 Dec 4;80(5):1103-5. doi: 10.1016/j.neuron.2013.11.016.

Abstract

Whether cortical projection neurons (CPNs) are generated by multipotent or fate-restricted progenitors is not completely understood. In this issue of Neuron, Guo et al. (2013) provide evidence that mouse Fezf2-expressing radial glial cells are multipotent progenitors that sequentially generate all major CPN subtypes and glia.

Publication types

  • Comment

MeSH terms

  • Animals
  • Astrocytes / metabolism*
  • DNA-Binding Proteins / metabolism*
  • Gene Expression Regulation, Developmental / physiology*
  • Multipotent Stem Cells / physiology*
  • Neocortex / cytology*
  • Nerve Tissue Proteins / metabolism*
  • Neurons / metabolism*
  • Oligodendroglia / metabolism*

Substances

  • DNA-Binding Proteins
  • Nerve Tissue Proteins
  • Zfp312 protein, mouse