Abstract
Immunoblot analysis was performed on the serum from 29 patients with polyneuropathy and monoclonal gammopathy. Nine patients had IgM spikes, and six of the nine had reactivity against myelin-associated glycoprotein (MAG) associated with a slowly progressive, predominantly sensory neuropathy. In contrast, 23 patients who lacked anti-MAG reactivity had more severe sensory motor neuropathy. Thus, IgM monoclonal gammopathy with reactivity against MAG may define a distinct clinical entity.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Aged
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Female
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Humans
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Hypergammaglobulinemia / blood
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Hypergammaglobulinemia / complications*
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Immunoglobulin G* / analysis
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Immunoglobulin M* / analysis
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Immunologic Techniques
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Male
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Middle Aged
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Movement Disorders / etiology
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Myelin Proteins / blood*
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Myelin-Associated Glycoprotein
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Nervous System Diseases / blood
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Nervous System Diseases / complications*
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Nervous System Diseases / physiopathology
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Sensation / physiology
Substances
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Immunoglobulin G
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Immunoglobulin M
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Myelin Proteins
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Myelin-Associated Glycoprotein