Role of polyethylene glycol in childhood constipation

Clin Pediatr (Phila). 2014 Sep;53(10):927-32. doi: 10.1177/0009922813505699. Epub 2013 Oct 9.

Abstract

Constipation is a common and chronic problem in children worldwide. Long-term use of laxatives is necessary for successful treatment of chronic constipation. Commonly used laxatives in children include milk of magnesia, lactulose, mineral oil, and polyethylene glycol (PEG). Recent studies report the efficacy and safety of PEG for the long-term treatment of constipation in children. Because of its excellent patient acceptance, PEG is being used widely in children for constipation. In this commentary, we review the recently published pediatric literature on the efficacy, safety, and patient acceptance of PEG. We also assess the role of PEG in childhood constipation by comparing it with other laxatives in terms of efficacy, safety, patient acceptance, and cost.

MeSH terms

  • Child
  • Clinical Trials as Topic
  • Constipation / drug therapy*
  • Defecation / drug effects*
  • Evidence-Based Medicine
  • Humans
  • Laxatives / administration & dosage
  • Laxatives / economics
  • Laxatives / therapeutic use*
  • Patient Satisfaction
  • Polyethylene Glycols / administration & dosage
  • Polyethylene Glycols / economics
  • Polyethylene Glycols / therapeutic use*
  • Randomized Controlled Trials as Topic
  • Treatment Outcome

Substances

  • Laxatives
  • Polyethylene Glycols
  • polyethylene glycol 3350