Aggregation formation in the polyglutamine diseases: protection at a cost?

Mol Cells. 2013 Sep;36(3):185-94. doi: 10.1007/s10059-013-0167-x. Epub 2013 Jun 19.

Abstract

Mutant protein aggregation is a hallmark of many neurodegenerative diseases, including the polyglutamine disorders. Although the correlation between aggregation formation and disease pathology originally suggested that the visible inclusions seen in patient tissue might directly contribute to pathology, additional studies failed to confirm this hypothesis. Current opinion in the field of polyglutamine disease research now favors a model in which large inclusions are cytoprotective and smaller oligomers or misfolded monomers underlie pathogenesis. Nonetheless, therapies aimed at reducing or preventing aggregation show promise. This review outlines the debate about the role of aggregation in the polyglutamine diseases as it has unfolded in the literature and concludes with a brief discussion on the manipulation of aggregation formation and clearance mechanisms as a means of therapeutic intervention.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • Mice
  • Mutant Proteins / chemistry*
  • Mutant Proteins / metabolism
  • Neurodegenerative Diseases / drug therapy
  • Neurodegenerative Diseases / genetics
  • Neurodegenerative Diseases / physiopathology*
  • Peptides / chemistry*
  • Peptides / metabolism
  • Protein Conformation
  • Protein Folding
  • Signal Transduction*

Substances

  • Mutant Proteins
  • Peptides
  • polyglutamine