Abstract
Little is known about the safety and effectiveness of excimer laser therapy when used in conjunction with other therapies in the treatment of mycosis fungoides (MF) lesions. We describe the use of adjunctive excimer laser therapy in combination with psoralen plus ultraviolet A (PUVA) and oral bexarotene for the treatment of recalcitrant and sanctuary plaques in a patient with MF. In our patient, this regimen successfully induced clinical and histologic resolution in MF plaques with minimal side effects limited to mild, short-lived tenderness and, rarely, local erythema. Our experience suggests that adjunctive excimer laser therapy with PUVA and oral bexarotene has the potential to be a safe, well-tolerated, and effective focal treatment regimen for cutaneous MF lesions.
MeSH terms
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Administration, Oral
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Anticarcinogenic Agents / administration & dosage
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Anticarcinogenic Agents / adverse effects
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Anticarcinogenic Agents / therapeutic use
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Bexarotene
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Combined Modality Therapy
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Ficusin / administration & dosage
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Follow-Up Studies
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Humans
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Lasers, Excimer / adverse effects
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Lasers, Excimer / therapeutic use*
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Male
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Middle Aged
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Mycosis Fungoides / pathology
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Mycosis Fungoides / therapy*
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PUVA Therapy / adverse effects
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PUVA Therapy / methods*
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Photosensitizing Agents / administration & dosage
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Skin Neoplasms / pathology
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Skin Neoplasms / therapy*
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Tetrahydronaphthalenes / administration & dosage
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Tetrahydronaphthalenes / adverse effects
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Tetrahydronaphthalenes / therapeutic use*
Substances
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Anticarcinogenic Agents
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Photosensitizing Agents
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Tetrahydronaphthalenes
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Bexarotene
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Ficusin