Goodness-of-fit test for proportional subdistribution hazards model

Stat Med. 2013 Sep 30;32(22):3804-11. doi: 10.1002/sim.5815. Epub 2013 Apr 28.

Abstract

This paper concerns using modified weighted Schoenfeld residuals to test the proportionality of subdistribution hazards for the Fine-Gray model, similar to the tests proposed by Grambsch and Therneau for independently censored data. We develop a score test for the time-varying coefficients based on the modified Schoenfeld residuals derived assuming a certain form of non-proportionality. The methods perform well in simulations and a real data analysis of breast cancer data, where the treatment effect exhibits non-proportional hazards.

Keywords: Martingale residual; competing risk; goodness-of-fit; hazard of subdistribution; proportional hazard; score test.

MeSH terms

  • Aged
  • Breast Neoplasms / drug therapy
  • Computer Simulation
  • Data Interpretation, Statistical*
  • Female
  • Humans
  • Neoplasm Recurrence, Local / prevention & control
  • Proportional Hazards Models*
  • Tamoxifen / therapeutic use

Substances

  • Tamoxifen