Cancer chromosomes going to POT1

Nat Genet. 2013 May;45(5):473-5. doi: 10.1038/ng.2617.

Abstract

Alterations in the single-stranded telomere-binding protein POT1 have recently been identified in chronic lymphocytic leukemia. This discovery provides novel insights into how genomic instability induced by dysfunctional telomeres contributes to tumorigenesis.

Publication types

  • Comment

MeSH terms

  • Exome / genetics*
  • Humans
  • Leukemia, Lymphocytic, Chronic, B-Cell / genetics*
  • Mutation / genetics*
  • Shelterin Complex
  • Telomere / genetics*
  • Telomere-Binding Proteins / genetics*

Substances

  • POT1 protein, human
  • Shelterin Complex
  • Telomere-Binding Proteins