Abstract
Alterations in the single-stranded telomere-binding protein POT1 have recently been identified in chronic lymphocytic leukemia. This discovery provides novel insights into how genomic instability induced by dysfunctional telomeres contributes to tumorigenesis.
MeSH terms
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Exome / genetics*
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Humans
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Leukemia, Lymphocytic, Chronic, B-Cell / genetics*
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Mutation / genetics*
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Shelterin Complex
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Telomere / genetics*
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Telomere-Binding Proteins / genetics*
Substances
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POT1 protein, human
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Shelterin Complex
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Telomere-Binding Proteins