Abstract
A small molecule, protein mimetic based approach is shown to specifically inhibit lipid catalysed self-assembly of islet amyloid polypeptide (IAPP). The lipid-bound oligomerization of this peptide is implicated in cellular dysfunction of insulin secreting β-cells in type II diabetes.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Carboxylic Acids / chemistry
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Cell Membrane
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Islet Amyloid Polypeptide / chemistry*
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Peptidomimetics
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Peptoids / chemistry
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Phosphatidylcholines / chemistry
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Phosphatidylglycerols / chemistry
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Quinolines / chemistry
Substances
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Carboxylic Acids
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Islet Amyloid Polypeptide
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Peptidomimetics
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Peptoids
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Phosphatidylcholines
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Phosphatidylglycerols
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Quinolines
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1,2-dioleoyl-sn-glycero-3-phosphoglycerol
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1,2-oleoylphosphatidylcholine