Combinatorial domain swaps provide insights into the rules of fungal polyketide synthase programming and the rational synthesis of non-native aromatic products

Angew Chem Int Ed Engl. 2013 Feb 4;52(6):1718-21. doi: 10.1002/anie.201208550. Epub 2013 Jan 2.

Authors

Anna L Vagstad¹, Adam G Newman, Philip A Storm, Katherine Belecki, Jason M Crawford, Craig A Townsend

Affiliation

¹ Department of Chemistry, The Johns Hopkins University, 3400 N. Charles St, Baltimore, MD 21218, USA.

No abstract available

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Catalytic Domain
Cyclization
Fungi / enzymology*
Metabolic Engineering
Polyketide Synthases / chemistry
Polyketide Synthases / metabolism*
Transaldolase / chemistry
Transaldolase / metabolism

Substances

Polyketide Synthases
Transaldolase

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