AgRP neurons: a switch between peripheral carbohydrate and lipid utilization

EMBO J. 2012 Nov 14;31(22):4252-4. doi: 10.1038/emboj.2012.287. Epub 2012 Oct 19.

Abstract

EMBO J (2012) 31 22, 4276–4288 doi:; DOI: 10.1038/emboj.2012.250; published online September 18 2012

AgRP/NPY neurons are critical regulators of body weight and food intake. Concordant with their orexigenic effects, it is expected that AgRP ablation leads to the appearance of a lean phenotype. In the current issue of The EMBO Journal, Joly-Amado et al (2012) describe an obese phenotype in a model of AgRP-ablated mice, and link it to a shift in metabolic profile in efferent tissues such as the liver, muscle and pancreas.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Agouti-Related Protein / metabolism*
  • Animals
  • Hypothalamus / metabolism*
  • Male

Substances

  • Agouti-Related Protein
  • Agrp protein, mouse