Abstract
The design of sensors to monitor the activity state of specific protein kinases is challenging due to the complexity of eukaryotic kinomes. Here we describe a peptide-based photaffinity probe that specifically labels the active conformation of the Abl tyrosine kinase.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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HEK293 Cells
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Humans
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Models, Molecular
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Molecular Sequence Data
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Peptides / chemistry*
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Peptides / metabolism*
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Photoaffinity Labels / chemistry*
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Photoaffinity Labels / metabolism*
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Protein Conformation
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Proto-Oncogene Proteins c-abl / chemistry*
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Proto-Oncogene Proteins c-abl / metabolism*
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Substrate Specificity
Substances
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Peptides
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Photoaffinity Labels
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Proto-Oncogene Proteins c-abl