Abstract
Vascular endothelial growth factor (VEGF) signalling induces embryonic vascular development and angiogenesis in adult tissues. Direct phosphorylation of the actin-binding protein profilin by VEGF receptors is now shown to increase its affinity for actin, and to be essential for adult but not embryonic arteriogenesis.
MeSH terms
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Actins / physiology
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Animals
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Mice
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Morphogenesis / physiology
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Neovascularization, Physiologic*
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Phosphorylation
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Profilins / metabolism*
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Receptors, Vascular Endothelial Growth Factor / physiology*
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Signal Transduction / physiology
Substances
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Actins
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Profilins
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Receptors, Vascular Endothelial Growth Factor