Profilin phosphorylation as a VEGFR effector in angiogenesis

Nat Cell Biol. 2012 Oct;14(10):985-7. doi: 10.1038/ncb2596.

Abstract

Vascular endothelial growth factor (VEGF) signalling induces embryonic vascular development and angiogenesis in adult tissues. Direct phosphorylation of the actin-binding protein profilin by VEGF receptors is now shown to increase its affinity for actin, and to be essential for adult but not embryonic arteriogenesis.

Publication types

  • News

MeSH terms

  • Actins / physiology
  • Animals
  • Mice
  • Morphogenesis / physiology
  • Neovascularization, Physiologic*
  • Phosphorylation
  • Profilins / metabolism*
  • Receptors, Vascular Endothelial Growth Factor / physiology*
  • Signal Transduction / physiology

Substances

  • Actins
  • Profilins
  • Receptors, Vascular Endothelial Growth Factor