Hormone resistance in diabetes and obesity: insulin, leptin, and FGF21

Jeffrey S Flier

Hormone resistance in diabetes and obesity: insulin, leptin, and FGF21

Yale J Biol Med. 2012 Sep;85(3):405-14. Epub 2012 Sep 25.

Author

Jeffrey S Flier¹

Affiliation

¹ Harvard University, Harvard Medical School, Boston, MA 02115, USA. Jeffrey_Flier@hms.harvard.edu

PMID: 23012588
PMCID: PMC3447204

Abstract

This an edited transcript of the Lee E. Farr Lecture given by Dr. Jeffrey Flier on May 8, 2012, at the culmination of the annual Student Research Day at the Yale School of Medicine. In this presentation, Dr. Flier discusses his and his wife's research on insulin, leptin, and FGF21 in the context of his reflections upon his life's work and his advice for young investigators.

Keywords: FGF21; Farr Lecture; diabetes; insulin; leptin; obesity.

Publication types

Lecture

MeSH terms

Adipose Tissue / metabolism
Adipose Tissue / physiopathology
Animals
Body Weight
Diabetes Mellitus / genetics
Diabetes Mellitus / metabolism
Diabetes Mellitus / physiopathology*
Diet, Ketogenic
Fatty Liver / metabolism
Fatty Liver / physiopathology
Fibroblast Growth Factors / genetics
Fibroblast Growth Factors / metabolism*
Humans
Insulin / genetics
Insulin / metabolism*
Insulin Resistance*
Leptin / metabolism*
Mice
Mice, Knockout
Obesity / metabolism
Obesity / physiopathology

Substances

Insulin
Leptin
fibroblast growth factor 21
Fibroblast Growth Factors